Deformable Registration of Supine and Prone Colons
CT colonography (CTC) is a minimally invasive screening technique for colorectal polyps and colon cancer. Most CTC protocols acquire both prone and supine images to improve the visualization of the lumen wall, reduce false positives, and improve sensitivity. Comparisons between the prone and supine images can be facilitated by computerized registration between the scans. In this paper, an algorithm for registering colons segmented from prone and supine images is presented. The algorithm uses feature matching of the colon centerline and a modified version of the demons deformable registration algorithm to define a deformation field between the prone and supine lumen surface. Experimental registration results, when used to determine polyp correspondence between prone and supine images, show an accuracy of 13.77 +/- 6.20 mm over 21 datasets with an average Jaccard similarity coefficients of 0.915 +/- 0.07.
Jung Wook Suh and Christopher L. Wyatt, Deformable Registration of Supine and Prone Colons For CT Colonography, Journal of Computer Assisted Tomography: November/December 2009 - Volume 33 - Issue 6 - pp 902-911 doi: 10.1097/RCT.0b013e3181a7e2c1.
J. W. Suh and C. L. Wyatt, Deformable Registration of Supine and Prone Colons Using Centerline Analysis, Proceedings of IEEE International Symposium on Biomedical Imaging, April 2007.
Code and Data
The code depends on ITK version 2.6 or greater and uses the TNT numerical template code from NIST. It has been built and tested on Linux-x86 (32 and 64 bit) and requires a machine with at least 1 GB of RAM to run properly.
Gzipped tar archive of code and example data: download.
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